Design of a Web Based Underwater Acoustic Communication Testbed and Simulation Platform

Wireless Personal Communications - Underwater Wireless Sensor Networks (UWSNs) are playing a vital role in exploring the unseen underwater (UW) natural resources. However, performance evaluation of...     

Molecular Recognition in C-Type Lectins: The Cases of DC-SIGN,Langerin, MGL,and L-Sectin

Carbohydrates play a pivotal role in intercellular communication processes. In particular, glycan antigens are key for sustaining homeostasis, helping leukocytes to distinguish damaged tissues and invading pathogens from healthy tissues. From a structural perspective, this cross-talk is fairly complex, and multiple membrane proteins guide these recognition processes, including lectins and Toll-like receptors. Since the beginning of this century, lectins have become potential targets for therapeutics for controlling and/or avoiding the progression of pathologies derived from an incorrect immune outcome, including infectious processes, cancer, or autoimmune diseases. Therefore, a detailed knowledge of these receptors is mandatory for the development of specific treatments. In this review, we summarize the current knowledge about four key C-type lectins whose importance has been steadily growing in recent years, focusing in particular on how glycan recognition takes place at the molecular level, but also looking at recent progresses in the quest for therapeutics.     

Dynamic wavelet-based pilot allocation algorithm for OFDM-based cognitive radio systems

In a cognitive radio system, the goal is to make better use of the radio electric spectrum, allowing non-licensed users access to those currently unused electromagnetic bands assigned to licensed users (LUs). This can be achieved using OFDM, where the non-licensed users must select the temporarily available subcarriers and turn off those subcarriers used by LUs in order to avoid interference. Hence, only a subset of the subcarriers can be used for data or pilot tone transmission. To this end, some pilot allocation algorithms have been proposed for this dynamic scenario, but they are designed in such away that an equispaced pilot placement is respected (as much as possible) while minimizing the mean squared error of the channel estimate. Nevertheless, this equispaced placement can lead to the use of an increased number of pilots in order to achieve a good channel estimation. In this work, a new pilot allocation algorithm based on wavelet transform is presented. The proposed algorithm uses the discrete wavelet transform to analyze the previous channel state information, taking the knowledge of the available subcarriers into account to provide a suboptimal solution for the pilot positions. This solution leads to a non-equispaced pilot placement, which improves the channel estimation and consequently, the system performance. Likewise, the introduced algorithm allows a reduction of the number of necessary pilots, which aids in increasing the data rate. Finally, simulation results corroborate the effectiveness of the algorithm in dynamic channel scenarios.     

Dendritic Nanotheranostic for the Delivery of Infliximab: A Potential Carrier in Rheumatoid Arthritis Therapy

Antibodies are macromolecules that specifically recognize their target, making them good candidates to be employed in various therapies. The possibility of attaching a drug to an immunoglobulin makes it possible to release it specifically into the affected tissue as long as it overexpresses the target. However, chemical coupling could affect the functionality (specificity and affinity) of the antibody. It has been observed that the use of intermediaries, such as dendrimers, could resolve this issue. Because carbosilane dendrimers have aroused great interest in the field of biomedicine, this report describes the synthesis of an anionic carbosilane dendrimer with a fluorochrome on its surface that then forms a conjugate with an antibody. It has been used as immunoglobulin and infliximab, whose target is TNF-α, which is a cytokine that is overexpressed in the inflamed area or even in the blood of patients with autoimmune diseases, such as rheumatoid arthritis. In addition, the integrity and functionality of the antibody has been studied to see if they have been affected after the chemical coupling process.     

Solid state reactions between SiC and Ir

Reactivity between SiC and Ir as a function of SiC-crystallinity was investigated by diffusion bonding technique under a vacuum and over the temperature range of 1200–1450 °C. As reaction products, various Ir-silicides and free unreacted-C were detected. Reactivity is strongly affected by the temperature and SiC-crystallinity involving a series of interactions, from “no reaction” to “massive exothermic reactions”. In particular, interfacial phenomena are more pronounced by the presence of defects and grain boundaries.Solid state reactions result in formation of fine C-precipitates rearranged in a quasi-periodic microstructure. On the contrary, clustering of highly ordered C-precipitates (C-graphitized) occurs after “massive reactions” take place.A relationship between the degree of graphitization (from 1 to multi-layers of graphene), temperature and SiC crystallinity was found by Raman spectroscopy. 2D-layering phenomenon is enhanced in polycrystalline SiC at high temperature.     

Scalable and flexible wireless distributed architecture for intelligent video surveillance systems

Multimedia Tools and Applications - This paper presents a novel distributed intelligent video surveillance architecture based on Wireless Multimedia Sensor Networks (WMSNs). This architecture is...